Lieven Lagae Selected Research

Myoclonic Epilepsies (Myoclonic Encephalopathy)

12/2021	Impact of fenfluramine on the expected SUDEP mortality rates in patients with Dravet syndrome.
9/2021	Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome.
1/2021	Dravet syndrome.
1/2021	A survey of the European Reference Network EpiCARE on clinical practice for selected rare epilepsies.
11/2020	Fenfluramine HCl (Fintepla® ) provides long-term clinically meaningful reduction in seizure frequency: Analysis of an ongoing open-label extension study.
1/2020	Why we urgently need improved seizure and epilepsy therapies for children and neonates.
12/2019	Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial.
1/2019	Drug repurposing for Dravet syndrome in scn1Lab-/- mutant zebrafish.
12/2018	Aberrant Inclusion of a Poison Exon Causes Dravet Syndrome and Related SCN1A-Associated Genetic Epilepsies.
10/2018	A pilot, open-label study of the effectiveness and tolerability of low-dose ZX008 (fenfluramine HCl) in Lennox-Gastaut syndrome.

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Lieven Lagae Research Topics

Disease

37	Epilepsy (Aura) 01/2022 - 09/2005
31	Seizures (Absence Seizure) 02/2022 - 09/2007
17	Tuberous Sclerosis (Bourneville's Disease) 01/2022 - 10/2015
17	Myoclonic Epilepsies (Myoclonic Encephalopathy) 12/2021 - 07/2004
13	Drug Resistant Epilepsy 01/2022 - 09/2005
6	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 01/2006
6	Epileptic Syndromes 01/2020 - 07/2004
5	Intellectual Disability (Idiocy) 01/2022 - 03/2016
4	Autism Spectrum Disorder 01/2022 - 06/2019
4	Brain Diseases (Brain Disorder) 09/2021 - 03/2016
4	Autistic Disorder (Autism) 01/2020 - 10/2002
3	Lennox Gastaut Syndrome 01/2022 - 10/2014
3	Neurodevelopmental Disorders 10/2021 - 05/2017
3	Infantile Spasms (West Syndrome) 01/2021 - 09/2005
3	Sleepiness 12/2019 - 07/2015
2	Fever (Fevers) 01/2022 - 07/2004
2	Developmental Disabilities (Developmental Disability) 01/2022 - 12/2018
2	Heart Valve Diseases (Valvular Heart Disease) 12/2019 - 10/2017
2	Status Epilepticus (Complex Partial Status Epilepticus) 12/2019 - 10/2014
2	Pulmonary Hypertension 10/2017 - 07/2012
2	Leukoencephalopathies 10/2016 - 05/2013
2	Dizziness (Lightheadedness) 01/2016 - 07/2015
1	Febrile Seizures (Febrile Seizure) 01/2022
1	Measles 01/2022
1	Sudden Unexpected Death in Epilepsy 12/2021
1	Nevus (Nevi) 12/2021
1	Autoimmune Diseases of the Nervous System 01/2021
1	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 01/2021
1	Cognitive Dysfunction 10/2020
1	Arnold-Chiari Malformation (Arnold-Chiari Syndrome) 09/2020
1	Congenital Abnormalities (Deformity) 01/2020
1	Fatigue 12/2019
1	Pulmonary Arterial Hypertension 12/2019
1	Lethargy 12/2019
1	Reflex Epilepsy (Photosensitive Epilepsy) 12/2019
1	Rare Diseases (Rare Disease) 12/2019
1	Hemorrhage 05/2019
1	Neuroinflammatory Diseases 01/2019
1	Inflammation (Inflammations) 12/2017
1	Obesity 10/2017
1	Infections 09/2017
1	Cerebral Small Vessel Diseases 10/2016
1	Cysts 10/2016
1	Headache (Headaches) 01/2016

Drug/Important Bio-Agent (IBA)

17	trans-sodium crocetinate (crocetin)IBA 01/2022 - 10/2015
16	Anticonvulsants (Antiepileptic Drugs)IBA 09/2021 - 09/2007
14	FenfluramineIBA 01/2022 - 07/2012
10	Pharmaceutical PreparationsIBA 01/2022 - 07/2015
4	Valproic Acid (Depakote)FDA LinkGeneric 01/2021 - 07/2004
4	Vigabatrin FDA Link 01/2021 - 09/2018
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 04/2016
3	CannabidiolIBA 01/2021 - 01/2020
3	Sodium Channels (Sodium Channel)IBA 12/2018 - 07/2004
3	perampanelIBA 01/2018 - 07/2015
2	Serotonin (5 Hydroxytryptamine)IBA 01/2022 - 05/2019
2	Mechanistic Target of Rapamycin Complex 1IBA 10/2021 - 01/2017
2	Everolimus FDA Link 01/2021 - 09/2018
2	Proteins (Proteins, Gene)FDA Link 10/2020 - 05/2019
2	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 01/2020 - 06/2016
2	SolutionsIBA 10/2018 - 08/2015
2	Voltage-Gated Sodium ChannelsIBA 05/2017 - 06/2016
2	SodiumIBA 05/2017 - 07/2008
2	TOR Serine-Threonine KinasesIBA 03/2016 - 10/2015
2	BenzodiazepinesIBA 10/2014 - 07/2004
2	Adrenocorticotropic Hormone (ACTH)FDA Link 12/2012 - 09/2005
1	Cell Adhesion MoleculesIBA 01/2022
1	LigandsIBA 01/2022
1	Serotonin ReceptorsIBA 01/2022
1	VaccinesIBA 01/2022
1	AntipyreticsIBA 01/2022
1	NorfenfluramineIBA 09/2021
1	Oxcarbazepine (Trileptal)FDA LinkGeneric 12/2020
1	SuspensionsIBA 12/2020
1	Carbamazepine (Tegretol)FDA LinkGeneric 12/2020
1	CarbohydratesIBA 01/2020
1	sec-butyl-propylacetamideIBA 12/2019
1	valnoctamideIBA 12/2019
1	Vesicular Monoamine Transport Proteins (Vesicular Monoamine Transporter)IBA 05/2019
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2019
1	PoisonsIBA 12/2018
1	RNA Polymerase IIIIBA 09/2017
1	Sodium Channel BlockersIBA 05/2017
1	Therapeutic UsesIBA 01/2017
1	NAD (NADH)IBA 01/2017
1	Small Nucleolar RNA (snoRNA)IBA 10/2016
1	Carrier Proteins (Binding Protein)IBA 06/2016
1	AMPA Receptors (AMPA Receptor)IBA 01/2016
1	AcidsIBA 01/2016

Therapy/Procedure

16	Therapeutics 01/2021 - 01/2012
7	Vagus Nerve Stimulation 05/2017 - 09/2007
3	Ketogenic Diet 01/2020 - 08/2009
2	Drug Substitution 02/2021 - 12/2008
2	Electrodes (Electrode) 01/2016 - 06/2013
2	Drug Therapy (Chemotherapy) 03/2012 - 05/2009
1	Wearable Electronic Devices 02/2022
1	Dermabrasion 12/2021
1	Precision Medicine 02/2021
1	Treatment Delay 01/2021
1	Decompression 09/2020
1	Renal Replacement Therapy (Therapies, Renal Replacement) 12/2018